Reduction of podocytes number in late diabetic alloxan nephropathy: prevention by glycemic control
نویسندگان
چکیده
منابع مشابه
Attenuation of Diabetic Nephropathy by Carvacrol through Anti-oxidative Effects in Alloxan-Induced Diabetic Rats
Background and Objectives: Diabetes, a common metabolic disorder, is prevalent in many countries. Nephropathy is a main debate’s side effect. Role of oxidative stress is well known in induction of diabetic nephropathy while carvacrol is a potent anti-oxidant that might attenuate oxidative stress. The aim of this study was to explore the effect of carvacrol in d...
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Insulin dependent diabetes mellitus (IDDM) is associated with several complications including painful diabetic neuropathy. Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. Furthermore, it has been suggested that glucose may be an important mediating factor in these painful symptoms. In the present study, pain threshold was assess...
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Introduction: According to the world health organization the prevalence of type 2 diabetes in our country and world will increase sharply by 2030. Because improving glycemic control delays the onset and progression of diabetes complications, recognizing related factors is key step in the effective treatment of these patients. Therefore, this study was performed to determine the predictors of po...
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We previously showed that the transcription factor Mafb is essential for podocyte differentiation and foot process formation. Podocytes are susceptible to injury in diabetes, and this injury leads to progression of diabetic nephropathy. In this study, we generated transgenic mice that overexpress Mafb in podocytes using the nephrin promoter/enhancer. To examine a potential pathogenetic role for...
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Vitamin D and its analogs have antiproteinuric activity and podocytes express the vitamin D receptor, but whether vitamin D signaling in podocytes accounts for this renoprotection is unknown. To investigate this question, we used the 2.5 kb podocin promoter to target Flag-tagged human vitamin D receptor (hVDR) to podocytes in DBA/2J mice. After the induction of diabetes with streptozotocin, tra...
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ژورنال
عنوان ژورنال: Acta Cirurgica Brasileira
سال: 2007
ISSN: 0102-8650
DOI: 10.1590/s0102-86502007000500003